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Ventilators May Be a Red Herring

Tues, Apr 14, 2020:

Governors are spending maximal effort procuring ventilators. But new research shows different results. Leaders may want to switch effort to blood substitutes, after conferring with front-line doctors/experts. That is, stop stockpiling ventilators, and get as much artificial blood as possible. Reasons are complex:

Doctors seeing patients with very low blood oxygen call this ARDS and assume that the lungs are not working well, while the blood hemoglobin and brain breathing-functions should be fine. They traditionally treat this with ventilator use to force air into the lungs, in order to save delicate brain & liver tissue requiring oxygen. Next they often induce a coma in order to keep the patient from clawing the ventilator tube out of their throat. Then, when the blood oxygen level is still obscenely low, they crank up the pressure in an attempt to force more oxygen in.

This has been resulting in 50%-80% deaths in ventilator patients, depending on the facility. The high pressure seems to blow out the lungs. And surviving sedated patients often have brain damage.

But front-line doctors are seeing several anomalies. Lung condition appears strong, not weak. People with bad lungs and low oxygen should have trouble getting rid of CO2; they should be gasping; their hearts should be racing; and they should almost be blacking out. The body has CO2 sensors, not O2 sensors, that kick in these range of reflexes when lungs are not working well to get rid of CO2. None of these are happening. The lungs are getting rid of CO2 well, indicating the lungs are working well. So typical ARDS protocols are not appropriate.

reference

But it turns out COVID-19 is a multi-talented supervirus. Not only does it attack sinuses, throat, lungs, and smell-center nerves; it is possible that it may also attack red blood cells and nerve centers that help control breathing. In particular one theory, which has problems, hypothesizes that the virus may somehow throw the iron out of hemoglobin. So this would stop the hemoglobin from binding oxygen, and also would also explain the excess poisonous iron loose in the body-- which would give the famous "ground glass" images in the lung X-rays. So when blood stops grabbing oxygen, the body breaks down rapidly, even when the lungs still work. There are problems with explaining just exactly how this is happening, but the overall reasoning explains many different effects.

The conclusions from this line of reasoning are several:

  1. non-invasive CPAPs prob. just as good as vents in most cases;
  2. ventilators, when used, should be dialed way down, not way up;
  3. ventilators won't work if hemoglobin or the oxygen-carrying function of blood is somehow defective
  4. replacing or augmenting blood with oxygen-binding blood substitutes is the way to go;
  5. hemoglobin-based (bovine) blood substitutes may not work either, so might perhaps need ? PFB-OC's;
  6. stop buying ventilators;
  7. start stockpiling: blood supplies; the cheap, orange-colored 5-second Wellue oximeter rings and Innovo oximeters; Gatorade;
  8. get front-line doctors and top researchers to start advising important leaders on this issue ASAP. Although several recent lines of research support these conclusions, we need expert opinion to confirm and validate these findings.

References:

flawed study, the specific mechanism proposed has been discredited. Overall idea may or may not still be valid. See following references: COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173

Flawed methods in “COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism”
https://chemrxiv.org/articles/Flawed_methods_in_COVID-19_Attacks_the_1-Beta_Chain_of_Hemoglobin_and_Captures_the_Porphyrin_to_Inhibit_Human_Heme_Metabolism_/12120912

Is Protocol-Driven Cov-19 Ventilation Doing More Harm Than Good?  https://www.medscape.com/viewarticle/928236

COVID-19 Does Not Lead to a 'Typical' ARDS 
https://www.atsjournals.org/doi/pdf/10.1164/rccm.202003-0817LE

Do COVID-19 Vent Protocols Need a Second Look?    
https://www.medscape.com/viewarticle/928156

Doctors say Ventilator are Overused for COVID-19   
https://www.statnews.com/2020/04/08/doctors-say-ventilators-overused-for-covid-19/

Resources

Growth-factor/Increase to 10x/1,000x Table
assumptions
GitHub source code for basic V.1 simulations

Articles

Ratings: E for Everyone; G for Government decision-makers; T for Technical.

--pending--